Aging - Theories and Potential Therapies.pdf (4,847 KB)
CONTENTS
Preface xi
Acknowledgments xiii
Introduction xv
1 The Quest for Immortality 1
One Hour upon the Stage 2
Growing Younger 7
The Road Ahead 7
2 Aging Theories 9
Error Catastrophe Theory 9
Genes and Programmed Aging 10
Telomeres 11
Rate-of-Living Theory 13
Free Radicals 14
Hormonal Imbalance Theory 14
Concluding Remarks 21
3 Age-Related Diseases 24
Alzheimer’s Disease 24
Arthritis 32
Cancer 33
Cardiovascular Disease 34
Diabetes 35
Osteoporosis 36
4 Antiaging Medicine 38
Hormone Therapy 39
Antioxidants 41
Caloric Restriction 41
Gene Therapy 42
5 The History of Gerontology 43
The Early Years 43
DNA Structure Inspires New Theories 45
Recombinant Technology Revolutionizes the Field 46
The Postgenomic Era 52
6 The Search for Longevity Genes 54
Yeast 55
Nematode 58
Fruit Fly 59
Mouse 62
Human 62
Summary 63
7 Geriatrics 65
Our Aging Society 66
Evaluating the Geriatric Patient 67
Managing Age-Related Disorders 68
Drug Therapy 71
Nursing Homes 72
Ethical Issues 73
8 Resource Center 75
Eukaryote Cell Primer 75
Recombinant DNA Primer 95
Gene Therapy Primer 106
The Human Genome Project 110
Glossary 115
Further Reading 141
Index 147
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